Drug interactions
Amobarbital + Metaxalone
Severity: Moderate
Amobarbital and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is a barbiturate that adds substantially to the sedative effect of metaxalone. As a CYP3A4 inducer, it may also lower metaxalone exposure and reduce its muscle relaxant benefit.
What this interaction means in plain words
Amobarbital and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depression plus induction of hepatic CYP3A4 metabolism of metaxalone by the barbiturate.
What to do
Monitor for excessive sedation and respiratory depression, and assess whether metaxalone is still effective. Adjust doses or consider an alternative if either problem occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Metaxalone?
MediHelp rates the interaction as moderate. Amobarbital and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital is a barbiturate that adds substantially to the sedative effect of metaxalone. As a CYP3A4 inducer, it may also lower metaxalone exposure and reduce its muscle relaxant benefit.
How serious is the interaction between Amobarbital and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, and assess whether metaxalone is still effective. Adjust doses or consider an alternative if either problem occurs.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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