Drug interactions
Amobarbital + Nebivolol
Severity: Minor
Amobarbital and Nebivolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and may reduce exposure to metabolized beta-blockers. Nebivolol is metabolized in part by CYP2D6 and glucuronidation, so the effect may be modest. Reduced beta-blockade could occur.
What this interaction means in plain words
Amobarbital and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Nebivolol belongs to Cardiovascular.
Why it happens
Enzyme induction by amobarbital may increase nebivolol clearance.
What to do
Monitor heart rate and blood pressure and adjust nebivolol dose if response is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Nebivolol?
MediHelp rates the interaction as minor. Amobarbital and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic enzymes and may reduce exposure to metabolized beta-blockers. Nebivolol is metabolized in part by CYP2D6 and glucuronidation, so the effect may be modest. Reduced beta-blockade could occur.
How serious is the interaction between Amobarbital and Nebivolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and adjust nebivolol dose if response is reduced.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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