Drug interactions
Amobarbital + Nicardipine
Severity: Moderate
Amobarbital and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and may reduce nicardipine concentrations, causing loss of blood pressure or angina control. Effects emerge over several days.
What this interaction means in plain words
Amobarbital and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Amobarbital induces hepatic and intestinal CYP3A4, increasing nicardipine metabolism.
What to do
Monitor blood pressure and anginal symptoms, and increase nicardipine dose if needed. Reassess dosing when the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Nicardipine?
MediHelp rates the interaction as moderate. Amobarbital and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and may reduce nicardipine concentrations, causing loss of blood pressure or angina control. Effects emerge over several days.
How serious is the interaction between Amobarbital and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and anginal symptoms, and increase nicardipine dose if needed. Reassess dosing when the barbiturate is stopped.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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