Drug interactions
Amobarbital + Propafenone
Severity: Moderate
Amobarbital and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and may lower propafenone concentrations. This may reduce antiarrhythmic efficacy and allow breakthrough arrhythmias.
What this interaction means in plain words
Amobarbital and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Propafenone belongs to Cardiovascular.
Why it happens
Amobarbital induces hepatic CYP enzymes (such as CYP3A4 and CYP1A2), increasing propafenone clearance.
What to do
Monitor for loss of rhythm control and ECG changes. Adjust the propafenone dose or choose an alternative sedative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Propafenone?
MediHelp rates the interaction as moderate. Amobarbital and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and may lower propafenone concentrations. This may reduce antiarrhythmic efficacy and allow breakthrough arrhythmias.
How serious is the interaction between Amobarbital and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of rhythm control and ECG changes. Adjust the propafenone dose or choose an alternative sedative.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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