Drug interactions
Amobarbital + Quinidine
Severity: Moderate
Amobarbital and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital can reduce quinidine concentrations and weaken its antiarrhythmic effect. Loss of efficacy may occur during treatment, and levels may rise after the barbiturate is stopped.
What this interaction means in plain words
Amobarbital and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Quinidine belongs to Anti Parasitic.
Why it happens
Barbiturate induction of hepatic CYP3A4 increases quinidine metabolism.
What to do
Monitor quinidine levels and ECG when starting or stopping the barbiturate and adjust the quinidine dose. Consider a non-inducing sedative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Quinidine?
MediHelp rates the interaction as moderate. Amobarbital and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital can reduce quinidine concentrations and weaken its antiarrhythmic effect. Loss of efficacy may occur during treatment, and levels may rise after the barbiturate is stopped.
How serious is the interaction between Amobarbital and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor quinidine levels and ECG when starting or stopping the barbiturate and adjust the quinidine dose. Consider a non-inducing sedative.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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