Drug interactions
Amoxapine + Lisdexamfetamine
Severity: Major
Amoxapine and Lisdexamfetamine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine blocks norepinephrine reuptake, and lisdexamfetamine is converted to dextroamphetamine. The combination may enhance cardiovascular stimulation, causing hypertension, tachycardia or arrhythmia, and raise serotonin toxicity risk.
What this interaction means in plain words
Amoxapine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive noradrenergic effects, with possible changes in amphetamine neuronal uptake and metabolism.
What to do
Avoid where an alternative exists. If used together, start low and monitor blood pressure, heart rate, ECG and mental status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Amoxapine with Lisdexamfetamine?
MediHelp rates the interaction as major. Amoxapine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amoxapine blocks norepinephrine reuptake, and lisdexamfetamine is converted to dextroamphetamine. The combination may enhance cardiovascular stimulation, causing hypertension, tachycardia or arrhythmia, and raise serotonin toxicity risk.
How serious is the interaction between Amoxapine and Lisdexamfetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where an alternative exists. If used together, start low and monitor blood pressure, heart rate, ECG and mental status.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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