Drug interactions
Amoxapine + Posaconazole
Severity: Moderate
Amoxapine and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes, especially with electrolyte disturbances or underlying heart disease. Amoxapine's QT effect is mainly seen in overdose or at high exposure.
What this interaction means in plain words
Amoxapine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac potassium channel (hERG) blockade.
What to do
Obtain a baseline ECG and correct potassium and magnesium before starting. Repeat the ECG after initiation and consider an alternative antidepressant if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Amoxapine with Posaconazole?
MediHelp rates the interaction as moderate. Amoxapine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes, especially with electrolyte disturbances or underlying heart disease. Amoxapine's QT effect is mainly seen in overdose or at high exposure.
How serious is the interaction between Amoxapine and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before starting. Repeat the ECG after initiation and consider an alternative antidepressant if the QTc becomes markedly prolonged.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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