Drug interactions
Amoxapine + Prochlorperazine
Severity: Major
Amoxapine and Prochlorperazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine has dopamine-blocking activity and also can prolong the QT interval, adding to the same effects of prochlorperazine. The combination raises the risk of extrapyramidal symptoms, neuroleptic malignant syndrome, arrhythmia and sedation.
What this interaction means in plain words
Amoxapine and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive dopamine D2 blockade, QT prolongation and CNS depression.
What to do
Avoid the combination if possible. If used, obtain a baseline ECG, correct electrolytes, and monitor for movement disorders, fever, rigidity and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Amoxapine with Prochlorperazine?
MediHelp rates the interaction as major. Amoxapine and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amoxapine has dopamine-blocking activity and also can prolong the QT interval, adding to the same effects of prochlorperazine. The combination raises the risk of extrapyramidal symptoms, neuroleptic malignant syndrome, arrhythmia and sedation.
How serious is the interaction between Amoxapine and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, obtain a baseline ECG, correct electrolytes, and monitor for movement disorders, fever, rigidity and sedation.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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