Drug interactions
Amoxapine + Propofol
Severity: Moderate
Amoxapine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a sedating antidepressant that can add to the CNS depressant effect of propofol. Excess sedation, hypotension and slower recovery from anesthesia may result.
What this interaction means in plain words
Amoxapine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through antihistaminic and other sedative actions of amoxapine with GABA-A potentiation by propofol.
What to do
Titrate propofol to effect, expecting a reduced dose requirement. Monitor sedation level, blood pressure and ECG during and after the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Frequently asked questions
Can I take Amoxapine with Propofol?
MediHelp rates the interaction as moderate. Amoxapine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a sedating antidepressant that can add to the CNS depressant effect of propofol. Excess sedation, hypotension and slower recovery from anesthesia may result.
How serious is the interaction between Amoxapine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect, expecting a reduced dose requirement. Monitor sedation level, blood pressure and ECG during and after the procedure.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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