Drug interactions
Amobarbital + Propofol
Severity: Major
Amobarbital and Propofol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance GABA-A activity, and the combination produces additive sedation, hypotension and respiratory depression. Propofol requirements are usually reduced.
What this interaction means in plain words
Amobarbital and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor potentiation causing CNS and respiratory depression.
What to do
Reduce propofol dose and titrate slowly to effect, with continuous monitoring of oxygenation, ventilation and blood pressure. Ensure airway support is available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amobarbital and Propofol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Amobarbital with Propofol?
MediHelp rates the interaction as major. Amobarbital and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs enhance GABA-A activity, and the combination produces additive sedation, hypotension and respiratory depression. Propofol requirements are usually reduced.
How serious is the interaction between Amobarbital and Propofol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce propofol dose and titrate slowly to effect, with continuous monitoring of oxygenation, ventilation and blood pressure. Ensure airway support is available.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
