Drug interactions
Belladonna and opium + Propofol
Severity: Major
Belladonna and opium and Propofol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The opium component adds opioid-mediated respiratory and CNS depression to propofol. Sedation, hypotension and apnea risk are increased.
What this interaction means in plain words
Belladonna and opium and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via opioid receptor agonism and GABA-A potentiation.
What to do
Reduce propofol dosing and titrate slowly with continuous monitoring of oxygen saturation, ventilation and blood pressure. Ensure airway equipment and opioid reversal are available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propofol
Frequently asked questions
Can I take Belladonna and opium with Propofol?
MediHelp rates the interaction as major. Belladonna and opium and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The opium component adds opioid-mediated respiratory and CNS depression to propofol. Sedation, hypotension and apnea risk are increased.
How serious is the interaction between Belladonna and opium and Propofol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce propofol dosing and titrate slowly with continuous monitoring of oxygen saturation, ventilation and blood pressure. Ensure airway equipment and opioid reversal are available.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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