Drug interactions
Amoxicillin + Hydrochlorothiazide-valsartan
Severity: Minor
Amoxicillin and Hydrochlorothiazide-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both amoxicillin and hydrochlorothiazide are cleared by renal tubular secretion, so they may compete and modestly raise each other's levels. The effect is generally small and rarely of clinical consequence with normal renal function.
What this interaction means in plain words
Amoxicillin and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amoxicillin belongs to Anti Bacterial; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Competition for renal tubular secretion via organic anion transporters.
What to do
No routine dose change is needed. Consider monitoring in patients with significant renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amoxicillin and Hydrochlorothiazide-valsartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
Frequently asked questions
Can I take Amoxicillin with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as minor. Amoxicillin and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both amoxicillin and hydrochlorothiazide are cleared by renal tubular secretion, so they may compete and modestly raise each other's levels. The effect is generally small and rarely of clinical consequence with normal renal function.
How serious is the interaction between Amoxicillin and Hydrochlorothiazide-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Consider monitoring in patients with significant renal impairment.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
