Drug interactions
Amoxicillin-clavulanic acid + Clarithromycin
Severity: Minor
Amoxicillin-clavulanic acid and Clarithromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macrolides are bacteriostatic and may theoretically reduce the bactericidal effect of amoxicillin. The combination is routinely used, for example in Helicobacter pylori regimens, without evident loss of efficacy.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Clarithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amoxicillin-clavulanic acid belongs to Anti Bacterial; Clarithromycin belongs to Anti Bacterial.
Why it happens
Theoretical pharmacodynamic antagonism between a bacteriostatic macrolide and a growth-dependent bactericidal beta-lactam.
What to do
No routine change is needed. Monitor clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Clarithromycin?
MediHelp rates the interaction as minor. Amoxicillin-clavulanic acid and Clarithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Macrolides are bacteriostatic and may theoretically reduce the bactericidal effect of amoxicillin. The combination is routinely used, for example in Helicobacter pylori regimens, without evident loss of efficacy.
How serious is the interaction between Amoxicillin-clavulanic acid and Clarithromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor clinical response.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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