Drug interactions
Amphetamine + Benzhydrocodone / acetaminophen
Severity: Moderate
Amphetamine and Benzhydrocodone / acetaminophen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase synaptic serotonin and some opioids have weak serotonergic activity, so the combination may rarely cause serotonin syndrome. Amphetamines may also counteract opioid sedation while worsening cardiovascular effects.
What this interaction means in plain words
Amphetamine and Benzhydrocodone / acetaminophen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity through amphetamine-induced monoamine release and opioid effects on serotonin reuptake.
What to do
Monitor for agitation, tremor, hyperreflexia, sweating and fever, especially at initiation and after dose changes. Stop the serotonergic agents if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amphetamine and Benzhydrocodone / acetaminophen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amphetamine
- Amphetamine + Iobenguane i Major
- Amphetamine + Ozanimod Major
- Amphetamine + Buprenorphine long-acting Moderate
- Amphetamine + Dextromethorphan Moderate
- Amphetamine + Epinephrine inhaled Moderate
- Amphetamine + Esketamine Moderate
Frequently asked questions
Can I take Amphetamine with Benzhydrocodone / acetaminophen?
MediHelp rates the interaction as moderate. Amphetamine and Benzhydrocodone / acetaminophen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines increase synaptic serotonin and some opioids have weak serotonergic activity, so the combination may rarely cause serotonin syndrome. Amphetamines may also counteract opioid sedation while worsening cardiovascular effects.
How serious is the interaction between Amphetamine and Benzhydrocodone / acetaminophen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperreflexia, sweating and fever, especially at initiation and after dose changes. Stop the serotonergic agents if serotonin syndrome is suspected.
What other medicines interact with Amphetamine?
MediHelp also lists interactions of Amphetamine with, for example, Iobenguane i, Ozanimod, Buprenorphine long-acting. The full list is on the Amphetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
