Drug interactions
Amphetamine + Ozanimod
Severity: Major
Amphetamine and Ozanimod: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolite inhibits MAO-B in vitro, and amphetamines release norepinephrine and dopamine, so a pressor response is possible. This could cause hypertensive crisis, although clinical data are limited.
What this interaction means in plain words
Amphetamine and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphetamine belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Potential MAO inhibition by ozanimod metabolites enhancing the sympathomimetic effects of amphetamine.
What to do
Avoid the combination where possible, since the labeling advises against use with drugs that increase norepinephrine. If used, monitor blood pressure and heart rate closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amphetamine
- Amphetamine + Iobenguane i Major
- Amphetamine + Benzhydrocodone / acetaminophen Moderate
- Amphetamine + Buprenorphine long-acting Moderate
- Amphetamine + Dextromethorphan Moderate
- Amphetamine + Epinephrine inhaled Moderate
- Amphetamine + Esketamine Moderate
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Amphetamine with Ozanimod?
MediHelp rates the interaction as major. Amphetamine and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod's active metabolite inhibits MAO-B in vitro, and amphetamines release norepinephrine and dopamine, so a pressor response is possible. This could cause hypertensive crisis, although clinical data are limited.
How serious is the interaction between Amphetamine and Ozanimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, since the labeling advises against use with drugs that increase norepinephrine. If used, monitor blood pressure and heart rate closely.
What other medicines interact with Amphetamine?
MediHelp also lists interactions of Amphetamine with, for example, Iobenguane i, Benzhydrocodone / acetaminophen, Buprenorphine long-acting. The full list is on the Amphetamine page.
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