Drug interactions
Amphetamine + Iobenguane i
Severity: Major
Amphetamine and Iobenguane i: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines affect catecholamine uptake and storage, and may block uptake of iobenguane into neuroendocrine tumor cells. This can reduce tumor uptake and therapeutic or diagnostic efficacy.
What this interaction means in plain words
Amphetamine and Iobenguane i can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Competition for norepinephrine transporter uptake and depletion of catecholamine stores reduce cellular iobenguane uptake.
What to do
Stop amphetamine for at least 5 half-lives before dosimetry or therapeutic doses, and do not restart until at least 7 days after each iobenguane dose, per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amphetamine
- Amphetamine + Ozanimod Major
- Amphetamine + Benzhydrocodone / acetaminophen Moderate
- Amphetamine + Buprenorphine long-acting Moderate
- Amphetamine + Dextromethorphan Moderate
- Amphetamine + Epinephrine inhaled Moderate
- Amphetamine + Esketamine Moderate
Frequently asked questions
Can I take Amphetamine with Iobenguane i?
MediHelp rates the interaction as major. Amphetamine and Iobenguane i can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amphetamines affect catecholamine uptake and storage, and may block uptake of iobenguane into neuroendocrine tumor cells. This can reduce tumor uptake and therapeutic or diagnostic efficacy.
How serious is the interaction between Amphetamine and Iobenguane i?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop amphetamine for at least 5 half-lives before dosimetry or therapeutic doses, and do not restart until at least 7 days after each iobenguane dose, per labeling.
What other medicines interact with Amphetamine?
MediHelp also lists interactions of Amphetamine with, for example, Ozanimod, Benzhydrocodone / acetaminophen, Buprenorphine long-acting. The full list is on the Amphetamine page.
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