Drug interactions
Amphetamine + Buprenorphine long-acting
Severity: Moderate
Amphetamine and Buprenorphine long-acting: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines increase serotonin and other monoamines, and opioids including buprenorphine have been associated with serotonin syndrome when combined with serotonergic drugs. The risk is low but the reaction can be serious.
What this interaction means in plain words
Amphetamine and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects with amphetamine-induced monoamine release.
What to do
Monitor for mental status changes, neuromuscular hyperactivity and autonomic instability, particularly at initiation or dose adjustment. Manage suspected serotonin syndrome by stopping the serotonergic drugs and giving supportive care.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphetamine
- Amphetamine + Iobenguane i Major
- Amphetamine + Ozanimod Major
- Amphetamine + Benzhydrocodone / acetaminophen Moderate
- Amphetamine + Dextromethorphan Moderate
- Amphetamine + Epinephrine inhaled Moderate
- Amphetamine + Esketamine Moderate
Frequently asked questions
Can I take Amphetamine with Buprenorphine long-acting?
MediHelp rates the interaction as moderate. Amphetamine and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines increase serotonin and other monoamines, and opioids including buprenorphine have been associated with serotonin syndrome when combined with serotonergic drugs. The risk is low but the reaction can be serious.
How serious is the interaction between Amphetamine and Buprenorphine long-acting?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status changes, neuromuscular hyperactivity and autonomic instability, particularly at initiation or dose adjustment. Manage suspected serotonin syndrome by stopping the serotonergic drugs and giving supportive care.
What other medicines interact with Amphetamine?
MediHelp also lists interactions of Amphetamine with, for example, Iobenguane i, Ozanimod, Benzhydrocodone / acetaminophen. The full list is on the Amphetamine page.
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