Drug interactions
Amphetamine + Epinephrine inhaled
Severity: Moderate
Amphetamine and Epinephrine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamine promotes release of norepinephrine and other catecholamines, and epinephrine directly stimulates adrenergic receptors. Together they can add to increases in heart rate and blood pressure and raise the risk of arrhythmia. Systemic exposure from inhaled epinephrine is usually low, so the effect is usually modest.
What this interaction means in plain words
Amphetamine and Epinephrine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic pharmacodynamic effects through indirect (amphetamine) and direct (epinephrine) adrenergic stimulation.
What to do
Monitor heart rate and blood pressure, especially when starting treatment or when epinephrine is used repeatedly. Limit epinephrine dosing to the recommended amount and review patients with cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amphetamine and Epinephrine inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amphetamine
- Amphetamine + Iobenguane i Major
- Amphetamine + Ozanimod Major
- Amphetamine + Benzhydrocodone / acetaminophen Moderate
- Amphetamine + Buprenorphine long-acting Moderate
- Amphetamine + Dextromethorphan Moderate
- Amphetamine + Esketamine Moderate
Frequently asked questions
Can I take Amphetamine with Epinephrine inhaled?
MediHelp rates the interaction as moderate. Amphetamine and Epinephrine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamine promotes release of norepinephrine and other catecholamines, and epinephrine directly stimulates adrenergic receptors. Together they can add to increases in heart rate and blood pressure and raise the risk of arrhythmia. Systemic exposure from inhaled epinephrine is usually low, so the effect is usually modest.
How serious is the interaction between Amphetamine and Epinephrine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, especially when starting treatment or when epinephrine is used repeatedly. Limit epinephrine dosing to the recommended amount and review patients with cardiovascular disease.
What other medicines interact with Amphetamine?
MediHelp also lists interactions of Amphetamine with, for example, Iobenguane i, Ozanimod, Benzhydrocodone / acetaminophen. The full list is on the Amphetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
