Drug interactions
Amphetamine + Esketamine
Severity: Moderate
Amphetamine and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine raises blood pressure and heart rate, and amphetamine produces similar sympathomimetic effects. Together they may cause greater hypertensive and tachycardic responses.
What this interaction means in plain words
Amphetamine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphetamine belongs to Central Nervous System; Esketamine belongs to Central Nervous System.
Why it happens
Additive sympathomimetic cardiovascular stimulation.
What to do
Measure blood pressure before dosing and about 40 minutes afterward, and again as clinically indicated. Delay or reconsider esketamine if baseline blood pressure is elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Amphetamine
Frequently asked questions
Can I take Amphetamine with Esketamine?
MediHelp rates the interaction as moderate. Amphetamine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine raises blood pressure and heart rate, and amphetamine produces similar sympathomimetic effects. Together they may cause greater hypertensive and tachycardic responses.
How serious is the interaction between Amphetamine and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure blood pressure before dosing and about 40 minutes afterward, and again as clinically indicated. Delay or reconsider esketamine if baseline blood pressure is elevated.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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