Drug interactions
Amphetamine + Esketamine intranasal
Severity: Moderate
Amphetamine and Esketamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise blood pressure and heart rate. Used together, the pressor effect may be greater, which is relevant in patients with hypertension or cardiovascular disease. Esketamine labeling advises monitoring blood pressure when it is combined with psychostimulants.
What this interaction means in plain words
Amphetamine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic and pressor effects from amphetamine-induced catecholamine release and esketamine's cardiovascular stimulation.
What to do
Measure blood pressure before dosing and about 40 minutes afterwards, and again as clinically indicated. If blood pressure is substantially elevated, reassess the combination or manage the hypertension before continuing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphetamine
Frequently asked questions
Can I take Amphetamine with Esketamine intranasal?
MediHelp rates the interaction as moderate. Amphetamine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise blood pressure and heart rate. Used together, the pressor effect may be greater, which is relevant in patients with hypertension or cardiovascular disease. Esketamine labeling advises monitoring blood pressure when it is combined with psychostimulants.
How serious is the interaction between Amphetamine and Esketamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure blood pressure before dosing and about 40 minutes afterwards, and again as clinically indicated. If blood pressure is substantially elevated, reassess the combination or manage the hypertension before continuing.
What other medicines interact with Amphetamine?
MediHelp also lists interactions of Amphetamine with, for example, Iobenguane i, Ozanimod, Benzhydrocodone / acetaminophen. The full list is on the Amphetamine page.
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