Drug interactions
Amphetamine + Sufentanil sl
Severity: Moderate
Amphetamine and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamine increases monoaminergic transmission and opioids can have serotonergic activity, so serotonin syndrome is possible with the combination. Sufentanil has weak serotonergic activity, so the risk is low but real. Symptoms include agitation, tremor, hyperreflexia, sweating and fever.
What this interaction means in plain words
Amphetamine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects, as amphetamine releases serotonin and opioids may inhibit its reuptake.
What to do
Observe for signs of serotonin syndrome, particularly at initiation and after dose changes. Stop the opioid or the stimulant and give supportive care if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphetamine
Frequently asked questions
Can I take Amphetamine with Sufentanil sl?
MediHelp rates the interaction as moderate. Amphetamine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamine increases monoaminergic transmission and opioids can have serotonergic activity, so serotonin syndrome is possible with the combination. Sufentanil has weak serotonergic activity, so the risk is low but real. Symptoms include agitation, tremor, hyperreflexia, sweating and fever.
How serious is the interaction between Amphetamine and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe for signs of serotonin syndrome, particularly at initiation and after dose changes. Stop the opioid or the stimulant and give supportive care if symptoms appear.
What other medicines interact with Amphetamine?
MediHelp also lists interactions of Amphetamine with, for example, Iobenguane i, Ozanimod, Benzhydrocodone / acetaminophen. The full list is on the Amphetamine page.
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