Drug interactions
Amphotericin b deoxycholate + Lomustine
Severity: Moderate
Amphotericin b deoxycholate and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conventional amphotericin B is markedly nephrotoxic and may cause infusion reactions with hypotension and bronchospasm. Lomustine, a nitrosourea, can also affect the kidneys and lungs, so concurrent use may increase toxicity. The interaction is largely theoretical.
What this interaction means in plain words
Amphotericin b deoxycholate and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism is not well established; likely additive nephrotoxic effects.
What to do
Monitor serum creatinine, potassium and magnesium frequently, and watch for infusion reactions. Maintain hydration and consider a lipid formulation or dose reduction if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Amphotericin b deoxycholate with Lomustine?
MediHelp rates the interaction as moderate. Amphotericin b deoxycholate and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conventional amphotericin B is markedly nephrotoxic and may cause infusion reactions with hypotension and bronchospasm. Lomustine, a nitrosourea, can also affect the kidneys and lungs, so concurrent use may increase toxicity. The interaction is largely theoretical.
How serious is the interaction between Amphotericin b deoxycholate and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and magnesium frequently, and watch for infusion reactions. Maintain hydration and consider a lipid formulation or dose reduction if renal function worsens.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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