Drug interactions
Delafloxacin + Magnesium sulphate
Severity: Moderate
Delafloxacin and Magnesium sulphate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral magnesium salts can bind delafloxacin in the gut, forming chelates that are poorly absorbed. This can lower delafloxacin concentrations and risk treatment failure. The concern applies to oral magnesium products, not intravenous magnesium.
What this interaction means in plain words
Delafloxacin and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Delafloxacin belongs to Anti Bacterial; Magnesium sulphate belongs to Cardiovascular.
Why it happens
Chelation of delafloxacin by divalent magnesium cations in the gastrointestinal tract reduces its absorption.
What to do
Give oral delafloxacin at least 2 hours before or 6 hours after oral magnesium-containing products.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
Other interactions of Delafloxacin
- Aluminum hydroxide + Delafloxacin Moderate
- Calcium carbonate + Delafloxacin Moderate
- Calcium + Delafloxacin Moderate
- Carbonyl iron + Delafloxacin Moderate
- Delafloxacin + Didanosine Moderate
- Delafloxacin + Ferrous fumarate Moderate
Frequently asked questions
Can I take Delafloxacin with Magnesium sulphate?
MediHelp rates the interaction as moderate. Delafloxacin and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral magnesium salts can bind delafloxacin in the gut, forming chelates that are poorly absorbed. This can lower delafloxacin concentrations and risk treatment failure. The concern applies to oral magnesium products, not intravenous magnesium.
How serious is the interaction between Delafloxacin and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral delafloxacin at least 2 hours before or 6 hours after oral magnesium-containing products.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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