Drug interactions
Amphotericin b phospholipid complex + Lomustine
Severity: Moderate
Amphotericin b phospholipid complex and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B lipid products can still cause kidney injury and infusion reactions with hypotension or bronchospasm. Lomustine may add to renal and pulmonary toxicity, though data are sparse. Patients may have worsened tolerability.
What this interaction means in plain words
Amphotericin b phospholipid complex and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism is not well established; likely additive nephrotoxic and cytotoxic effects.
What to do
Monitor renal function and electrolytes during co-therapy and observe during infusions. Reduce or hold amphotericin if creatinine rises significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Amphotericin b phospholipid complex with Lomustine?
MediHelp rates the interaction as moderate. Amphotericin b phospholipid complex and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B lipid products can still cause kidney injury and infusion reactions with hypotension or bronchospasm. Lomustine may add to renal and pulmonary toxicity, though data are sparse. Patients may have worsened tolerability.
How serious is the interaction between Amphotericin b phospholipid complex and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and electrolytes during co-therapy and observe during infusions. Reduce or hold amphotericin if creatinine rises significantly.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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