Drug interactions
Ampicillin + Omadacycline
Severity: Moderate
Ampicillin and Omadacycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bacteriostatic tetracyclines may blunt the killing activity of beta-lactams, which depend on actively dividing bacteria. The clinical importance is uncertain and mostly derived from in vitro and older clinical data. It may matter in serious infections such as meningitis or endocarditis.
What this interaction means in plain words
Ampicillin and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ampicillin belongs to Anti Bacterial; Omadacycline belongs to Anti Bacterial.
Why it happens
Bacteriostatic inhibition of protein synthesis slows bacterial growth, reducing the bactericidal effect of cell-wall-active beta-lactams.
What to do
Avoid the combination in severe infections where bactericidal activity is needed. If combined, monitor clinical response and consider using one agent alone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ampicillin
- Allopurinol + Ampicillin Moderate
- Ampicillin + Bcg vaccine live Moderate
- Ampicillin + Chloramphenicol Moderate
- Ampicillin + Chloroquine Moderate
- Ampicillin + Cholera vaccine Moderate
- Ampicillin + Demeclocycline Moderate
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Ampicillin with Omadacycline?
MediHelp rates the interaction as moderate. Ampicillin and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bacteriostatic tetracyclines may blunt the killing activity of beta-lactams, which depend on actively dividing bacteria. The clinical importance is uncertain and mostly derived from in vitro and older clinical data. It may matter in serious infections such as meningitis or endocarditis.
How serious is the interaction between Ampicillin and Omadacycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in severe infections where bactericidal activity is needed. If combined, monitor clinical response and consider using one agent alone.
What other medicines interact with Ampicillin?
MediHelp also lists interactions of Ampicillin with, for example, Allopurinol, Bcg vaccine live, Chloramphenicol. The full list is on the Ampicillin page.
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