Drug interactions
Anagrelide + Eliglustat
Severity: Major
Anagrelide and Eliglustat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat can prolong the PR, QRS and QTc intervals at high exposure, and anagrelide also prolongs the QT interval. The combination may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Anagrelide and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Eliglustat belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic prolongation of cardiac conduction and repolarization.
What to do
Avoid the combination if possible, particularly in patients with existing heart disease. If both are needed, obtain baseline and follow-up ECGs and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Anagrelide with Eliglustat?
MediHelp rates the interaction as major. Anagrelide and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat can prolong the PR, QRS and QTc intervals at high exposure, and anagrelide also prolongs the QT interval. The combination may increase the risk of ventricular arrhythmia.
How serious is the interaction between Anagrelide and Eliglustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, particularly in patients with existing heart disease. If both are needed, obtain baseline and follow-up ECGs and correct electrolytes.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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