Drug interactions
Anagrelide + Itraconazole
Severity: Moderate
Anagrelide and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide can prolong the QT interval and cause tachyarrhythmias, and itraconazole may add to the arrhythmic risk. Itraconazole may also reduce anagrelide clearance via CYP inhibition.
What this interaction means in plain words
Anagrelide and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anagrelide belongs to Cardiovascular; Itraconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation and possible CYP inhibition affecting anagrelide metabolism.
What to do
Obtain a baseline ECG and monitor QTc and heart rate, correcting electrolytes. Consider an alternative antifungal in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Itraconazole?
MediHelp rates the interaction as moderate. Anagrelide and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anagrelide can prolong the QT interval and cause tachyarrhythmias, and itraconazole may add to the arrhythmic risk. Itraconazole may also reduce anagrelide clearance via CYP inhibition.
How serious is the interaction between Anagrelide and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and heart rate, correcting electrolytes. Consider an alternative antifungal in patients with cardiac risk factors.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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