Drug interactions
Anagrelide + Lurasidone
Severity: Moderate
Anagrelide and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower blood pressure, lurasidone through alpha-1 adrenergic blockade and anagrelide through vasodilation. Together they may produce additive hypotension and orthostatic symptoms, particularly at initiation or after dose increases.
What this interaction means in plain words
Anagrelide and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anagrelide belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Additive vasodilatory and alpha-1 blocking pharmacodynamic effects on blood pressure.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Counsel the patient to rise slowly and reduce doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Lurasidone?
MediHelp rates the interaction as moderate. Anagrelide and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower blood pressure, lurasidone through alpha-1 adrenergic blockade and anagrelide through vasodilation. Together they may produce additive hypotension and orthostatic symptoms, particularly at initiation or after dose increases.
How serious is the interaction between Anagrelide and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Counsel the patient to rise slowly and reduce doses if symptomatic hypotension occurs.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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