Drug interactions
Anagrelide + Promethazine
Severity: Major
Anagrelide and Promethazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The concurrent use of promethazine and anagrelide may lead to a significant reduction in the QTc interval, which can increase the risk of cardiac arrhythmias. Patients taking both medications should be monitored closely for any signs of cardiac irregularities.
What this interaction means in plain words
Anagrelide and Promethazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Promethazine belongs to Respiratory.
Why it happens
Both drugs are known to influence cardiac repolarization, potentially leading to alterations in the QT interval. The exact pharmacological interactions contributing to this effect are not fully understood.
What to do
It is advisable to avoid co-administration of these drugs whenever possible. If their use together is necessary, continuous cardiac monitoring is recommended to detect any potential arrhythmias early.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Promethazine?
MediHelp rates the interaction as major. Anagrelide and Promethazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The concurrent use of promethazine and anagrelide may lead to a significant reduction in the QTc interval, which can increase the risk of cardiac arrhythmias. Patients taking both medications should be monitored closely for any signs of cardiac irregularities.
How serious is the interaction between Anagrelide and Promethazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: It is advisable to avoid co-administration of these drugs whenever possible. If their use together is necessary, continuous cardiac monitoring is recommended to detect any potential arrhythmias early.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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