Drug interactions
Anagrelide + Rivaroxaban
Severity: Moderate
Anagrelide and Rivaroxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide inhibits platelet aggregation and reduces platelet counts, so together with rivaroxaban it can increase bleeding risk. Patients with essential thrombocythemia often have other bleeding risk factors as well.
What this interaction means in plain words
Anagrelide and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anagrelide belongs to Cardiovascular; Rivaroxaban belongs to Cardiovascular.
Why it happens
Additive effects on hemostasis: platelet inhibition and thrombocytopenia from anagrelide plus factor Xa inhibition from rivaroxaban.
What to do
Monitor platelet counts and watch for signs of bleeding. Reassess the need for both agents if platelet counts fall or bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Rivaroxaban?
MediHelp rates the interaction as moderate. Anagrelide and Rivaroxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anagrelide inhibits platelet aggregation and reduces platelet counts, so together with rivaroxaban it can increase bleeding risk. Patients with essential thrombocythemia often have other bleeding risk factors as well.
How serious is the interaction between Anagrelide and Rivaroxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and watch for signs of bleeding. Reassess the need for both agents if platelet counts fall or bleeding occurs.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
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