Drug interactions
Anakinra + Golimumab
Severity: Major
Anakinra and Golimumab: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anakinra with TNF blockers has been linked to more serious infections and neutropenia without added efficacy.
What this interaction means in plain words
Anakinra and Golimumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anakinra belongs to Musculoskeletal; Golimumab belongs to Musculoskeletal.
Why it happens
Additive immunosuppression from TNF-alpha and IL-1 receptor blockade.
What to do
Do not combine; use a single biologic. Monitor for infection and neutrophils when switching.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Anakinra and Golimumab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Frequently asked questions
Can I take Anakinra with Golimumab?
MediHelp rates the interaction as major. Anakinra and Golimumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Anakinra with TNF blockers has been linked to more serious infections and neutropenia without added efficacy.
How serious is the interaction between Anakinra and Golimumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a single biologic. Monitor for infection and neutrophils when switching.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
