Drug interactions
Anakinra + Hydroxychloroquine
Severity: Minor
Anakinra and Hydroxychloroquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxychloroquine is only a mild immunomodulator, so additional infection risk with anakinra is small. The combination is used in rheumatic disease without major problems.
What this interaction means in plain words
Anakinra and Hydroxychloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Anakinra belongs to Musculoskeletal; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
Mild additive immunomodulation; no meaningful pharmacokinetic interaction.
What to do
No change needed; monitor for infection as is routine with anakinra.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Frequently asked questions
Can I take Anakinra with Hydroxychloroquine?
MediHelp rates the interaction as minor. Anakinra and Hydroxychloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydroxychloroquine is only a mild immunomodulator, so additional infection risk with anakinra is small. The combination is used in rheumatic disease without major problems.
How serious is the interaction between Anakinra and Hydroxychloroquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change needed; monitor for infection as is routine with anakinra.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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