Drug interactions
Anakinra + Ozanimod
Severity: Moderate
Anakinra and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anakinra blocks interleukin-1 signalling while ozanimod sequesters lymphocytes in lymphoid tissue, so using both can compound immune suppression. This may raise the risk of serious infection, and the effect of ozanimod on lymphocyte counts can persist after it is stopped.
What this interaction means in plain words
Anakinra and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anakinra belongs to Musculoskeletal; Ozanimod belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic immunosuppression through IL-1 receptor blockade and S1P receptor-mediated lymphocyte sequestration.
What to do
Monitor closely for signs of infection and check lymphocyte and neutrophil counts periodically during combined use. Consider the prolonged immune effect of ozanimod when switching therapies.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Anakinra with Ozanimod?
MediHelp rates the interaction as moderate. Anakinra and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anakinra blocks interleukin-1 signalling while ozanimod sequesters lymphocytes in lymphoid tissue, so using both can compound immune suppression. This may raise the risk of serious infection, and the effect of ozanimod on lymphocyte counts can persist after it is stopped.
How serious is the interaction between Anakinra and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for signs of infection and check lymphocyte and neutrophil counts periodically during combined use. Consider the prolonged immune effect of ozanimod when switching therapies.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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