Drug interactions
Anakinra + Temsirolimus
Severity: Major
Anakinra and Temsirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anakinra blocks interleukin-1 signalling while temsirolimus inhibits mTOR, and both suppress immune function. Used together they may raise the risk of serious infections beyond that of either drug alone.
What this interaction means in plain words
Anakinra and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anakinra belongs to Musculoskeletal; Temsirolimus belongs to Oncology.
Why it happens
Additive pharmacodynamic immunosuppression through IL-1 receptor antagonism and mTOR inhibition.
What to do
Avoid the combination where an alternative exists. If both are required, monitor closely for signs of infection and withhold therapy if a serious infection develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Anakinra with Temsirolimus?
MediHelp rates the interaction as major. Anakinra and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Anakinra blocks interleukin-1 signalling while temsirolimus inhibits mTOR, and both suppress immune function. Used together they may raise the risk of serious infections beyond that of either drug alone.
How serious is the interaction between Anakinra and Temsirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists. If both are required, monitor closely for signs of infection and withhold therapy if a serious infection develops.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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