Drug interactions
Anastrozole + Ranolazine
Severity: Minor
Anastrozole and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anastrozole is a weak CYP3A inhibitor in vitro, so ranolazine levels could theoretically rise. At clinical doses the effect is not expected to be meaningful.
What this interaction means in plain words
Anastrozole and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Anastrozole belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 inhibition by anastrozole reducing ranolazine metabolism.
What to do
No adjustment is usually required. Be aware of dose-related ranolazine effects such as dizziness or QT prolongation if symptoms arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Anastrozole
- Anastrozole + Bazedoxifene / conjugated estrogens Contraindicated
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Anastrozole + Conjugated estrogens Contraindicated
- Anastrozole + Estradiol Contraindicated
- Anastrozole + Estrogens conjugated synthetic Contraindicated
- Anastrozole + Estrogens esterified Contraindicated
Frequently asked questions
Can I take Anastrozole with Ranolazine?
MediHelp rates the interaction as minor. Anastrozole and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Anastrozole is a weak CYP3A inhibitor in vitro, so ranolazine levels could theoretically rise. At clinical doses the effect is not expected to be meaningful.
How serious is the interaction between Anastrozole and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is usually required. Be aware of dose-related ranolazine effects such as dizziness or QT prolongation if symptoms arise.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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