Drug interactions
Ansofaxine + Lisdexamfetamine
Severity: Major
Ansofaxine and Lisdexamfetamine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ansofaxine is a serotonin-norepinephrine-dopamine reuptake inhibitor and lisdexamfetamine releases monoamines including serotonin. The combination can increase the risk of serotonin syndrome and additive cardiovascular stimulation.
What this interaction means in plain words
Ansofaxine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic and noradrenergic activity from reuptake inhibition and amphetamine-induced monoamine release.
What to do
Use the lowest effective doses and monitor for serotonin syndrome and blood pressure changes, especially during initiation or titration. Discontinue the serotonergic agents if toxicity develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ansofaxine and Lisdexamfetamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Ansofaxine with Lisdexamfetamine?
MediHelp rates the interaction as major. Ansofaxine and Lisdexamfetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ansofaxine is a serotonin-norepinephrine-dopamine reuptake inhibitor and lisdexamfetamine releases monoamines including serotonin. The combination can increase the risk of serotonin syndrome and additive cardiovascular stimulation.
How serious is the interaction between Ansofaxine and Lisdexamfetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for serotonin syndrome and blood pressure changes, especially during initiation or titration. Discontinue the serotonergic agents if toxicity develops.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
