Drug interactions
Anti-thymocyte + Azathioprine
Severity: Moderate
Anti-thymocyte and Azathioprine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithymocyte globulin is often used with azathioprine in transplant regimens, but the combination adds to immunosuppression and myelosuppression. Infection and cytopenia risk is increased.
What this interaction means in plain words
Anti-thymocyte and Azathioprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anti-thymocyte belongs to Miscellaneous; Azathioprine belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression and bone marrow suppression.
What to do
Monitor blood counts and infection signs, and adjust azathioprine dose for leukopenia. Use standard antimicrobial prophylaxis per transplant protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anti-thymocyte
- Anti-thymocyte + Bcg vaccine live Contraindicated
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicated
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live Contraindicated
- Anti-thymocyte + Measles vaccine Contraindicated
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicated
Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Frequently asked questions
Can I take Anti-thymocyte with Azathioprine?
MediHelp rates the interaction as moderate. Anti-thymocyte and Azathioprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithymocyte globulin is often used with azathioprine in transplant regimens, but the combination adds to immunosuppression and myelosuppression. Infection and cytopenia risk is increased.
How serious is the interaction between Anti-thymocyte and Azathioprine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and infection signs, and adjust azathioprine dose for leukopenia. Use standard antimicrobial prophylaxis per transplant protocol.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.
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