Drug interactions
Anticholinergic / sedative combos + Prochlorperazine
Severity: Moderate
Anticholinergic / sedative combos and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining prochlorperazine with anticholinergic and sedative products adds to anticholinergic and sedative effects, such as confusion, constipation, urinary retention and drowsiness. Anticholinergics may also slow gastrointestinal transit and reduce absorption of oral phenothiazines.
What this interaction means in plain words
Anticholinergic / sedative combos and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic and CNS depressant effects; delayed gastric emptying may alter oral absorption.
What to do
Monitor for anticholinergic toxicity and sedation, especially in older adults. Use the lowest doses needed and consider alternatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Anticholinergic / sedative combos with Prochlorperazine?
MediHelp rates the interaction as moderate. Anticholinergic / sedative combos and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining prochlorperazine with anticholinergic and sedative products adds to anticholinergic and sedative effects, such as confusion, constipation, urinary retention and drowsiness. Anticholinergics may also slow gastrointestinal transit and reduce absorption of oral phenothiazines.
How serious is the interaction between Anticholinergic / sedative combos and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and sedation, especially in older adults. Use the lowest doses needed and consider alternatives.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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