Drug interactions
Antithymocyte globulin equine + Human papillomavirus vaccine
Severity: Moderate
Antithymocyte globulin equine and Human papillomavirus vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Equine antithymocyte globulin depletes T lymphocytes and causes profound immunosuppression, which can blunt the antibody response to HPV vaccination. Vaccine-induced protection may therefore be incomplete or short-lived.
What this interaction means in plain words
Antithymocyte globulin equine and Human papillomavirus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
T-cell depletion by the antithymocyte globulin impairs the immune response to the inactivated vaccine.
What to do
Give HPV vaccine before starting antithymocyte globulin when feasible. If vaccinated during or soon after treatment, consider revaccination or antibody assessment once immune recovery has occurred.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
- Elivaldogene autotemcel + Human papillomavirus vaccine Moderate
Frequently asked questions
Can I take Antithymocyte globulin equine with Human papillomavirus vaccine?
MediHelp rates the interaction as moderate. Antithymocyte globulin equine and Human papillomavirus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Equine antithymocyte globulin depletes T lymphocytes and causes profound immunosuppression, which can blunt the antibody response to HPV vaccination. Vaccine-induced protection may therefore be incomplete or short-lived.
How serious is the interaction between Antithymocyte globulin equine and Human papillomavirus vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give HPV vaccine before starting antithymocyte globulin when feasible. If vaccinated during or soon after treatment, consider revaccination or antibody assessment once immune recovery has occurred.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin rabbit, Atidarsagene autotemcel, Belimumab. The full list is on the Human papillomavirus vaccine page.
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