Drug interactions
Cyclosporine + Human papillomavirus vaccine
Severity: Moderate
Cyclosporine and Human papillomavirus vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine suppresses T-cell function and may blunt the antibody response to HPV vaccination. Reduced immunogenicity could leave the patient inadequately protected.
What this interaction means in plain words
Cyclosporine and Human papillomavirus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition suppresses T-cell-dependent immune responses to the vaccine.
What to do
Where feasible, complete vaccination at least 2 weeks before starting cyclosporine. If vaccinated during therapy, consider antibody assessment or revaccination once immunosuppression is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Elivaldogene autotemcel + Human papillomavirus vaccine Moderate
Frequently asked questions
Can I take Cyclosporine with Human papillomavirus vaccine?
MediHelp rates the interaction as moderate. Cyclosporine and Human papillomavirus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine suppresses T-cell function and may blunt the antibody response to HPV vaccination. Reduced immunogenicity could leave the patient inadequately protected.
How serious is the interaction between Cyclosporine and Human papillomavirus vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible, complete vaccination at least 2 weeks before starting cyclosporine. If vaccinated during therapy, consider antibody assessment or revaccination once immunosuppression is reduced.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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