Drug interactions
Atidarsagene autotemcel + Human papillomavirus vaccine
Severity: Moderate
Atidarsagene autotemcel and Human papillomavirus vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaccine safety and efficacy during or after atidarsagene autotemcel treatment have not been studied. Myeloablative conditioning eliminates the recipient's immune memory and the immune system rebuilds afterwards, so vaccination in this window is unlikely to be effective.
What this interaction means in plain words
Atidarsagene autotemcel and Human papillomavirus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atidarsagene autotemcel belongs to Miscellaneous; Human papillomavirus vaccine belongs to Miscellaneous.
Why it happens
Myeloablative conditioning and hematopoietic reconstitution impair vaccine responses.
What to do
Give vaccines at least 6 weeks before myeloablative conditioning where feasible. Defer vaccination until hematologic recovery, then revaccinate according to guidelines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
- Elivaldogene autotemcel + Human papillomavirus vaccine Moderate
Other interactions of Atidarsagene autotemcel
Frequently asked questions
Can I take Atidarsagene autotemcel with Human papillomavirus vaccine?
MediHelp rates the interaction as moderate. Atidarsagene autotemcel and Human papillomavirus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vaccine safety and efficacy during or after atidarsagene autotemcel treatment have not been studied. Myeloablative conditioning eliminates the recipient's immune memory and the immune system rebuilds afterwards, so vaccination in this window is unlikely to be effective.
How serious is the interaction between Atidarsagene autotemcel and Human papillomavirus vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give vaccines at least 6 weeks before myeloablative conditioning where feasible. Defer vaccination until hematologic recovery, then revaccinate according to guidelines.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Belimumab. The full list is on the Human papillomavirus vaccine page.
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