Drug interactions
Cortisone + Human papillomavirus vaccine
Severity: Moderate
Cortisone and Human papillomavirus vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids at higher than physiologic doses suppress immune function and may reduce the antibody response to vaccines. Protection after HPV vaccination may be lower in patients on sustained high-dose therapy.
What this interaction means in plain words
Cortisone and Human papillomavirus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid-mediated suppression of lymphocyte function reduces vaccine immunogenicity.
What to do
Non-live HPV vaccine can be given to patients on corticosteroids. Where possible vaccinate when the dose is low or before starting prolonged high-dose therapy, and consider checking response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cortisone and Human papillomavirus vaccine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
- Elivaldogene autotemcel + Human papillomavirus vaccine Moderate
Frequently asked questions
Can I take Cortisone with Human papillomavirus vaccine?
MediHelp rates the interaction as moderate. Cortisone and Human papillomavirus vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids at higher than physiologic doses suppress immune function and may reduce the antibody response to vaccines. Protection after HPV vaccination may be lower in patients on sustained high-dose therapy.
How serious is the interaction between Cortisone and Human papillomavirus vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Non-live HPV vaccine can be given to patients on corticosteroids. Where possible vaccinate when the dose is low or before starting prolonged high-dose therapy, and consider checking response.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
