Drug interactions
Antithymocyte globulin equine + Leflunomide
Severity: Major
Antithymocyte globulin equine and Leflunomide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Equine antithymocyte globulin causes profound T-cell depletion, and adding leflunomide further impairs immune defence. This increases the risk of serious and opportunistic infections and of myelosuppression.
What this interaction means in plain words
Antithymocyte globulin equine and Leflunomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression from T-cell depletion and inhibition of lymphocyte proliferation.
What to do
Avoid combining where possible. If both are required, monitor closely for infection and check blood counts frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Antithymocyte globulin equine with Leflunomide?
MediHelp rates the interaction as major. Antithymocyte globulin equine and Leflunomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Equine antithymocyte globulin causes profound T-cell depletion, and adding leflunomide further impairs immune defence. This increases the risk of serious and opportunistic infections and of myelosuppression.
How serious is the interaction between Antithymocyte globulin equine and Leflunomide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If both are required, monitor closely for infection and check blood counts frequently.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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