Drug interactions
Apalutamide + Atorvastatin
Severity: Moderate
Apalutamide and Atorvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and can substantially lower atorvastatin exposure. The LDL-lowering effect may be reduced.
What this interaction means in plain words
Apalutamide and Atorvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Atorvastatin belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 increases atorvastatin metabolism.
What to do
Monitor lipid profile and adjust the atorvastatin dose, or switch to a statin not dependent on CYP3A4 such as rosuvastatin or pravastatin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Atorvastatin?
MediHelp rates the interaction as moderate. Apalutamide and Atorvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer and can substantially lower atorvastatin exposure. The LDL-lowering effect may be reduced.
How serious is the interaction between Apalutamide and Atorvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid profile and adjust the atorvastatin dose, or switch to a statin not dependent on CYP3A4 such as rosuvastatin or pravastatin.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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