Drug interactions
Apalutamide + Belzutifan
Severity: Moderate
Apalutamide and Belzutifan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belzutifan is a CYP3A4 inducer and may lower apalutamide exposure. Apalutamide, as a strong CYP3A4 inducer, may in turn reduce belzutifan levels, which are cleared partly by UGT2B17 and CYP2C19 and CYP3A4.
What this interaction means in plain words
Apalutamide and Belzutifan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Belzutifan belongs to Miscellaneous.
Why it happens
Both agents induce CYP3A4, and belzutifan reduces exposure of CYP3A4 substrates such as apalutamide.
What to do
Monitor efficacy of both drugs, including PSA response for apalutamide and tumor response for belzutifan. Adjust doses based on clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Apalutamide and Belzutifan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Belzutifan
Frequently asked questions
Can I take Apalutamide with Belzutifan?
MediHelp rates the interaction as moderate. Apalutamide and Belzutifan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belzutifan is a CYP3A4 inducer and may lower apalutamide exposure. Apalutamide, as a strong CYP3A4 inducer, may in turn reduce belzutifan levels, which are cleared partly by UGT2B17 and CYP2C19 and CYP3A4.
How serious is the interaction between Apalutamide and Belzutifan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor efficacy of both drugs, including PSA response for apalutamide and tumor response for belzutifan. Adjust doses based on clinical response.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
