Drug interactions
Apalutamide + Chlorpropamide
Severity: Moderate
Apalutamide and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces CYP2C9, which may lower chlorpropamide exposure and reduce its glucose-lowering effect. Loss of glycemic control is possible, though chlorpropamide is also largely cleared unchanged by the kidney, which may limit the effect.
What this interaction means in plain words
Apalutamide and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Chlorpropamide belongs to Endocrine.
Why it happens
Induction of CYP2C9 by apalutamide increases the metabolism of chlorpropamide.
What to do
Monitor blood glucose after starting or stopping apalutamide and increase the chlorpropamide dose if control worsens. Reduce the dose again if apalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Chlorpropamide?
MediHelp rates the interaction as moderate. Apalutamide and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide induces CYP2C9, which may lower chlorpropamide exposure and reduce its glucose-lowering effect. Loss of glycemic control is possible, though chlorpropamide is also largely cleared unchanged by the kidney, which may limit the effect.
How serious is the interaction between Apalutamide and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping apalutamide and increase the chlorpropamide dose if control worsens. Reduce the dose again if apalutamide is stopped.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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