Drug interactions
Apalutamide + Clonazepam
Severity: Moderate
Apalutamide and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide, a strong CYP3A4 inducer, may lower clonazepam concentrations because clonazepam is metabolized partly by CYP3A4. Reduced anxiolytic or anticonvulsant effect is possible, with a risk of breakthrough seizures in epilepsy.
What this interaction means in plain words
Apalutamide and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Clonazepam belongs to Central Nervous System.
Why it happens
CYP3A4 induction by apalutamide increases clonazepam metabolism and lowers its plasma levels.
What to do
Monitor for loss of seizure or symptom control after apalutamide is started and increase the clonazepam dose if necessary. Reassess the dose if apalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Clonazepam?
MediHelp rates the interaction as moderate. Apalutamide and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide, a strong CYP3A4 inducer, may lower clonazepam concentrations because clonazepam is metabolized partly by CYP3A4. Reduced anxiolytic or anticonvulsant effect is possible, with a risk of breakthrough seizures in epilepsy.
How serious is the interaction between Apalutamide and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of seizure or symptom control after apalutamide is started and increase the clonazepam dose if necessary. Reassess the dose if apalutamide is stopped.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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