Drug interactions
Apalutamide + Deflazacort
Severity: Major
Apalutamide and Deflazacort: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide reduces exposure to deflazacort's active metabolite, which can cause loss of efficacy. Deflazacort labeling advises against strong CYP3A4 inducers.
What this interaction means in plain words
Apalutamide and Deflazacort can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Deflazacort belongs to Miscellaneous.
Why it happens
Strong CYP3A4 induction accelerates clearance of the active metabolite 21-desDFZ.
What to do
Avoid concomitant use of deflazacort with strong CYP3A4 inducers; use an alternative corticosteroid if apalutamide is required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Apalutamide with Deflazacort?
MediHelp rates the interaction as major. Apalutamide and Deflazacort can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide reduces exposure to deflazacort's active metabolite, which can cause loss of efficacy. Deflazacort labeling advises against strong CYP3A4 inducers.
How serious is the interaction between Apalutamide and Deflazacort?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use of deflazacort with strong CYP3A4 inducers; use an alternative corticosteroid if apalutamide is required.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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