Drug interactions
Apalutamide + Diazepam
Severity: Moderate
Apalutamide and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces CYP3A4 and CYP2C19, which both contribute to the metabolism of diazepam and its active metabolite. Diazepam exposure can fall, leading to loss of anxiolytic, anticonvulsant or sedative effect.
What this interaction means in plain words
Apalutamide and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Diazepam belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 and CYP2C19 by apalutamide increases diazepam clearance.
What to do
Monitor for reduced diazepam efficacy and increase the dose if needed, or switch to a benzodiazepine that is not metabolized by oxidation, such as lorazepam. Reassess the dose when apalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Apalutamide and Diazepam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Diazepam
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Diazepam?
MediHelp rates the interaction as moderate. Apalutamide and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide induces CYP3A4 and CYP2C19, which both contribute to the metabolism of diazepam and its active metabolite. Diazepam exposure can fall, leading to loss of anxiolytic, anticonvulsant or sedative effect.
How serious is the interaction between Apalutamide and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced diazepam efficacy and increase the dose if needed, or switch to a benzodiazepine that is not metabolized by oxidation, such as lorazepam. Reassess the dose when apalutamide is stopped.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
