Drug interactions
Apalutamide + Dipyridamole
Severity: Minor
Apalutamide and Dipyridamole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is an enzyme and transporter inducer that may lower exposure to dipyridamole. Reduced antiplatelet or vasodilatory effect is possible, though the clinical impact is not well characterized.
What this interaction means in plain words
Apalutamide and Dipyridamole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Dipyridamole belongs to Cardiovascular.
Why it happens
Apalutamide induces metabolic enzymes and transporters such as BCRP, potentially increasing dipyridamole elimination.
What to do
Monitor for reduced antiplatelet efficacy, and consider an alternative agent if thrombotic events occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Dipyridamole?
MediHelp rates the interaction as minor. Apalutamide and Dipyridamole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Apalutamide is an enzyme and transporter inducer that may lower exposure to dipyridamole. Reduced antiplatelet or vasodilatory effect is possible, though the clinical impact is not well characterized.
How serious is the interaction between Apalutamide and Dipyridamole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antiplatelet efficacy, and consider an alternative agent if thrombotic events occur.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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